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Tuesday, July 13, 2021

Chemical Leukoderma

The condition is not physically harmful but it is disfiguring. 01062012 Chemical leukoderma is a chemically-induced acquired hypopigmented dermatosis 1.


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We report a case of chemical leukoderma induced by a transdermal methylphenidate medicated patch for the treatment of attention deficit hyperactive disorder ADHD.

Chemical leukoderma. 01112008 Contact or chemical leukoderma refers to depigmentation related to application of certain chemical compounds to the skin. We identified 51 cases of chemical leukoderma reported with the use of MTS. Most of these chemicals are phenols and ar.

Chemical leukoderma represents an acquired vitiligo-like hypomelanosis induced by repeated exposure to specific chemical compounds. Chemical leukoderma often clinically mimicking idiopathic vitiligo and other congenital and acquired hypopigmentation is an acquired form of cutaneous pigment loss caused by exposure to a variety of chemicals that act through selective melanocytotoxicity. 10022016 Chemical leukoderma sometimes called occupational vitiligo is the loss of areas of skin pigment due to contact with certain chemicals.

Dimethyl sulfate is an industrial alkylating. 26112008 Chemical leukoderma is histologically identical to vitiligo and may be hard to distinguish clinically except by specific exposure history of the area6 The depigmentation can be precipitated by a contact dermatitis with eczematous changes or can arise without prior symptoms7 Some authors distinguish chemical leukoderma from occupational. Chemical leukoderma also known as contact leukoderma denotes an acquired hypopigmentation caused by repeated exposure to specific chemical compounds eg lead-based cosmetics skin bleaching agents like hydroquinone etc known to destroy the skin pigment cells melanocytes 12.

01012017 Chemical leukoderma syndrome ranges from chemical leukoderma confined to the site of contact only stage I to a distant spread of depigmented patches 1 year after the discontinuation of the offending agent stage IV. Depigmented areas may continue to arise even after the patient is no longer in contact with the chemicals. 1-5 The majority of these chemicals are aromatic or aliphatic derivatives of phenols or catechols.

As is often the case in chemical leukoderma it was diagnosed as vitiligo in 19 cases. Chemical leukoderma refers to an acquired hypopigmented dermatosis induced by repeated exposure of the skin to specific chemical compounds. 1 case did not provide enough information to confirm the affected site.

Vitiligo is an acquired skin. These substances may be toxic to melanocytes or may compete with tyrosine for hydroxylation by tyrosinase thereby impeding synthesis of melanin in melanocytes. Most of these chemicals are phenols and aromatic or aliphatic catechols derivatives.

Leukoderma occurs on the exposed parts of the body but other areas not necessarily in contact with the chemicals may also be affected. This chemical effect independent of their sensitizing potential is distinctly separate from post-inflammatory depigmentation and Koebner in vitiligo. 27062017 Chemical leukoderma is an acquired hypopigmented dermatosis that results from repeated cutaneous application of an agent that destroys epidermal melanocytes8The occurrence with repeated exposure to a suspected depigmenting agent helps to differentiate it from vitiligo.

02032020 Chemical leukoderma also known as contact leukoderma or occupational vitiligo is an acquired depigmenting dermatosis caused by repeated or sometimes a single exposure to specific chemicals. Chemical leukoderma is a skin condition that causes the skin to lose color due to repeated exposure to specific chemical compounds. Chemical leukoderma often clinically mimicking idiopathic vitiligo and other congenital and acquired hypopigmentation is an acquired form of cutaneous pigment loss caused by exposure to a variety of chemicals that act through selective melanocytotoxicity.

Contact leukoderma is the loss of skin colour whitening of skin following contact with chemicals known to destroy the skin pigment cells melanocytes. Repigmentation may or may not occur. The median age was 11 years.

43 cases reported leukoderma at or near the application site only and 7 reported leukoderma at other parts of the body in addition to the application site. Chemical leukoderma may develop both at the site of contact with the chemical as well as remotely from the exposure. It is also known as chemical leukoderma and may be spelt leucoderma.

28102011 Chemical leukoderma is defined as an acquired hypopigmented dermatosis that results from repeated cutaneous application of an agent that destroys epidermal melanocytes in genetically susceptible patients. And anyone can suffer from it whether they have a history of vitiligo or not. 6 7 We report two cases of chemical leukoderma induced by dimethyl sulfate.

It is usually due to chemicals found in the workplace but it can also follow the use of certain cosmetic products.


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